Long COVID: Assessment, Diagnosis, and Management of Symptoms

This page offers clinical resources and education for evaluating and managing adults experiencing Long COVID symptoms, gathered through ACP’s participation in a collaboration across medical specialty societies to disseminate such guidance.
Included is expert guidance, largely gathered from Long COVID clinics treating patients across the United States, as well as DynaMedex®. Also offered here are educational resources from the ACP Washington Chapter and recent articles published in Annals of Internal Medicine related to Long COVID.
Featured Resources
- Long COVID Resource Repository (CMSS) — Developed by the Council of Medical Specialty Societies, this resource repository provides a curated collection of tools and guidance for primary care clinicians managing Long COVID. This repository covers a wide range of symptoms and provides evidence-based information to help clinicians overcome challenges in diagnosis and treatment. By addressing gaps in current knowledge, the repository enables clinicians to make confident, informed decisions in patient care.
- Multidisciplinary Collaborative Guidance on the Assessment and Treatment of Patients with Long COVID: A Compendium Statement — This resource published by the journal of the American Academy of Physical Medicine and Rehabilitation, PM&R, provides a symptom-by-symptom guide to diagnosis and treatment of Long COVID.
- Long COVID Videos — Discover expert insights into the complications of Long COVID with the following videos discussing the importance of early detection, accurate diagnosis, and comprehensive care strategies and highlighting the vital role of internal medicine physicians in supporting patients with Long COVID. Additional videos in this series further explore Long COVID complications and care approaches by offering a deeper look into this evolving field.
DynaMedex: Post-COVID-19 Condition (Long COVID)
This collection of resources from DynaMedex covers Long COVID evaluation, management, prevention, and more.
Long COVID Definitions and Models of Care: A Scoping Review
Definitions of Long COVID and care models are evolving, but considerable variability is seen in these models, according to a review published online on May 21, 2024 in the Annals of Internal Medicine.
Long COVID Studies
Economically Disadvantaged Patients at Greater Risk for Long COVID
A prospective observational cohort study, published in the Annals of Internal Medicine, found that people with social risk factors including economic instability and food insecurity at the time of COVID-19 infection were at greater risk for Long COVID.
CBT and Rehabilitation Improved Long COVID Symptoms
This ACP Journal Club study looks to determine which interventions improve symptoms for Long COVID, concluding cognitive behavioral therapy (CBT) and physical and mental health rehabilitation improved symptoms more than usual care.
This project is supported by the Centers for Disease Control and Prevention of the U.S. Department of Health and Human Services (HHS) as part of a financial assistance award totaling $25,000 with 100 percent funding by CDC/HHS. The contents are those of the author(s) and do not necessarily represent the official views of, nor an endorsement, by CDC/HHS, or the U.S. Government.